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ea0019p300 | Reproduction | SFEBES2009

Plasma kisspeptin levels in hypertensive diseases of pregnancy and the identification of kisspeptin in amniotic fluid

Nijher G , Dhillo W , Chaudhri O , Murphy K , Ramachandran R , Fowler A , Chinthapalli K , Patterson M , Thompson E , Williamson C , Kumar S , Ghatei M , Bloom S

Kisspeptin, encoded by the KiSS-1 gene activates the G protein coupled receptor 54 (GPR54). The kisspeptin/GPR54 system plays an essential role regulating reproductive development. The human placenta has a high expression of both the KiSS-1 and GPR54 genes. Plasma kisspeptin levels increase several thousand fold in pregnancy. The physiological role of kisspeptin in pregnancy is not clear. Kisspeptin causes vasoconstriction during in vitro studies and may play a r...

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ea0019oc4 | Young Endocrinologist prize session | SFEBES2009

Kisspeptin potently increases reproductive hormone release in women with hypothalamic amenorrhoea: a potential novel therapy for infertility

Jayasena CN , Chaudhri OB , Nijher GK , Murphy KG , Ranger A , Lim A , Patel D , Mehta A , Todd C , Ramachandran R , Salem V , Stamp GW , Donaldson M , Ghatei MA , Bloom SR , Dhillo WS

Background: Kisspeptin is a critical regulator of normal reproductive function. In humans inactivating mutations of the kisspeptin receptor GPR54 cause hypogonadotrophic hypogonadism and pubertal failure. Activating mutations of GPR54 cause precocious puberty. Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. In rodent models of HA hypothalamic KISS1 expressi...

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Endocrine Abstracts

Plasma kisspeptin levels in hypertensive diseases of pregnancy and the identification of kisspeptin in amniotic fluid

Kisspeptin potently increases reproductive hormone release in women with hypothalamic amenorrhoea: a potential novel therapy for infertility

BiosciAbstracts